During the Roman Empire, what we now call Prati district, consisted of an expanse of reeds and vineyards owned by the wife of Domitian, Domitia (Horti Domitii). Starting from 1870 began the first steps of construction and urbanization. An element of particular interest is the urban layout of the streets: after the unification of Italy, because of the strained relations with the Holy See, the neighborhood was built in such a way that from any point you could see the Dome of the Basilica of S . Peter; furthermore to all the streets of the neighborhood were given names of historical figures of the Republican and Imperial Rome, leaders and literary men of classical latin and pagan heritage (eg. Via Orazio, where the Vatican Domus is ubicated) and heroes of the Risorgimento’s period.
Not far from the Vatican Domus you may find...

Piazza Cavour
Dedicated to the statesman Camille Benso Count of Cavour; on the square there are: Adriano Theatre, built in 1898 and now turned into a multiplex cinema, and the Palace of Justice, completed in 1911 and renamed "Palazzaccio" because inspired to the NeoBaroque architecture; now it is the seat of the Supreme Court of Cassation.

Castel Sant’Angelo
Also known as the Mausoleum of Adriano (Mole Adrianorum). Started by Emperor Adriano in 125 AD, as his funerary mausoleum, it was completed by Antoninus Pius in 139 AD. The Mausoleum owes its current name following an episode that took place in 590 AD; during that year the city of Rome was hit by a severe pestilence and to put an end to it Pope Gregory I organized a penitential procession. In the vicinity of the Mausoleum, the pope had a vision of the Archangel Michael sheathing his sword, this was interpreted as a sign from God that foretold the end of the epidemic, which is what happened.

Basilica di San Pietro
The present Basilica stands on the ruins of the ancient Basilica, built by the Roman Emperor Constantine I in the fourth century, because according to tradition right there was buried S. Peter, the first of Jesus apostles. The actual Basilica was begun under Pope Julius II in 1506 and completed in 1626 under Pope Urban VIII.